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    Chlorpheniramine

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    dr.aml fathi
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    تاريخ التسجيل : 18/11/2010

    Chlorpheniramine

    مُساهمة من طرف dr.aml fathi في الإثنين أغسطس 15, 2011 11:09 pm


    Chlorpheniramine



    Trade
    names in egyptian market:



    Anallerge® tab , syrup … allergyl® tab , syrup ….. pirafene® tab


    Class:
    Antihistamines,1st Generation




    Dosing Forms


    Tablets , syrup ,Extended-release tablets , Extended-release capsules, Sustained-release capsules



    Dose:


    *Adult: 4 mg q4-6hr (max dose:24mg/day)

    *6-12 years old :2 mg q4-6hr (max dose: 12 mg /day)

    *2-6 years old: 1 mg q4-6hr (max dose: 6 mg /day)

    *LESS THAN 2 YEARS : Safety & efficacy not established



    Uses & indications:


    -Allergic rhinitis


    -Perennialطوال السنة& seasonal allergic &vasomotor rhinitis(ليست نتيجة حساسية
    او عدوى)


    -relief of symptoms fromcolds, urticaria, angioedema, anaphylactic reactions, pruritus, allergic conjunctivitis



    Pregnancy& Lactation


    Lactation: excretion in milk unknown/not recommended



    Pregnancy Category: C
    , this means that it is Used with caution if benefits outweigh risks



    Contraindications


    -Documented hypersensitivity

    -Lower respiratory disease, eg, asthma (controversial)

    -Preemies (premature infants) & neonates

    -Nursing women

    -Acute asthma, sleep apnea



    Cautions


    Caution in narrow angle glaucoma, prostatic hypertrophy, stenosing
    peptic ulcer, pyloroduodenal obstruction, or bladder neck obstruction



    Pharmacology


    *Half-Life: 12-43 hr

    *Duration: 24 hr

    *Onset: 6 hr

    *Peak Plasma Time: 2-6 hr

    *Protein Bound: 69-72%

    *Metabolism: GI mucosa, liver

    *Excretion: urine

    *Sedative effect: low

    *Antihistamine activity: moderate

    *Anticholinergic acitivity: moderate


    Mechanism
    of Action



    Histamine H1-receptor antagonist


    Storage

    Store at 25C .Protect from light


    Side effects:

    Frequency Not Defined

    CNS depression , Drowsiness , Sedation ranging from mild drowsiness to deep sleep (most frequent)

    Dizziness , Lassitude , Disturbed coordination , Muscular weakness
    , Restlessness, insomnia, tremors, euphoria, nervousness, delirium palpitation(abnormalityof heartbeat), seizures is less common

    Epigastric distress , Anorexia , Nausea , Vomiting , Diarrhea ,Constipation, Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice is rare

    Tachycardia, palpitation ECG changes (eg, widened QRS)

    Arrhythmias (eg, extrasystole, heart block)

    Hypotension , Hypertension , Dizziness, sedation, and hypotension may
    occur in geriatric patients

    Dryness of mouth, nose, and throat , Dysuria , Urinary retention , Impotence


    Drug Interactions:



    Serious Interactions with isocarboxazid , oxybate & tranylcypromine, so Use Alternative:

    isocarboxazid {Monoamine oxidase inhibitors (MAOIs)} increases
    effects of chlorpheniramine by Other (see comment). Serious - Use Alternative.
    Comment: Isocarboxazid should not be administered in combination with antihistamines

    chlorpheniramine, sodium oxybate. Either increases effects of the
    other by pharmacodynamic synergism. Serious - Use Alternative. Additive CNS depression.


    tranylcypromine increases effects of chlorpheniramine by Other.
    Serious - Use Alternative. Tranylcypromine should not be administered in combination with antihistamines because of potential additive CNS depressant
    effects. MAO inhibitors also prolong and intensify anticholinergic effects of antihistamines.


    Moderate interactions:


    Anticholinergic drugs, such as:

    Atropine ,Belladonna, Benztropine ,Clidinium, Clozapine ,Darifenacin, Dicyclomine , Diphenhydramine ,Glycopyrrolate, Haloperidol ,Homatropine ,Hyoscyamine, Ipratropium ,Oxybutynin


    Other products that cause drowsiness, such as:

    Alcohol ,Antipsychotic medications ,Anxiety medications ,Most antidepressants ,Muscle relaxants ,Narcotic pain relievers,Sleep medications ,Some antihistamines


    Phenothiazine medications, such as:

    Chlorpromazine, Fluphenazine ,Perphenazine ,Prochlorperazine ,Thioridazine ,Trifluoperazine


















      الوقت/التاريخ الآن هو الأربعاء أكتوبر 18, 2017 11:58 pm